However today’s computerized medical diagnostic systems are used for different medical purposes, but there are some limitations must be regarded for the varying performance and high error rate often seen in the clinical decision-support systems; so many ethical issues get raised in the implementation of medical diagnostic systems. Goodman and Miller determined the set of key ethical principles for appropriate use of medical decision-support systems as:

1. A computer program should be used in clinical practice only after appropriate evaluation of its efficacy and documentation that it performs its intended task at an acceptable cost in time and money.
2. Users of most clinical systems should be health professionals who are qualified to address the question on hand on the basis of their licensure, clinical training and experience. Software systems should be used to augment or supplement, rather than to replace or supplant, such individuals’ decision making.
3. All uses of informatics tools, especially in patient care, should be preceded by adequate training and instructions, which should include review of all available forms of previous product evaluations.

Also in dealing with often life altering diseases and treatments in the practice of medicine, it is important that medical diagnostic systems designers understand the ramifications of mistakes in their programming or their systems; all the good intentions will not bring a patient back to life following a computer-generated clinical systems error. Those who uses clinical programs must rely on the work of others who are frequently far removed from the context of use. Users depend on the developers and maintainers of a system and must trust evaluators who have validated a system for clinical use. Conversely, patients must trust that their physicians or clinicians are familiar with the informatics, computer or decision-support systems to utilize them properly. Clinicians have an ethical obligation to be familiar with this evidence after attaining minimal acceptable levels of familiarity with informatics in general and with the clinical systems they use in particular.